Partial adenosine A1 receptor agonists for cardiovascular therapies
نویسندگان
چکیده
منابع مشابه
Selective Inhibitory Effect of Adenosine A1 Receptor Agonists on the Proliferation of Human Tumor Cell Lines
Background: In this study, the effects of three structural analogues of adenosine upon proliferation of human tumor cells were investigated. Previous research showed a cytotoxic effect of adenosine via A3 receptor and A1 receptor and sometimes this effect was receptor independent. The researches showed a differential cytotoxic effect of adenosine and its A3 agonists on cancerous cells, while ot...
متن کاملAnti-Inflammatory Preconditioning by Agonists of Adenosine A1 Receptor
BACKGROUND Adenosine levels rise during inflammation and modulate inflammatory responses by engaging with four different G protein-coupled receptors. It is suggested that adenosine exhibits pro-inflammatory effects through its A(1) receptor (A(1)R), and anti-inflammatory effects through A(2A) receptor (A(2A)R). Therefore, understanding of the mechanisms that govern adenosine receptor regulation...
متن کامل8-Alkylamino-substituted analogs of N6-cyclopentyladenosine are partial agonists for the cardiovascular adenosine A1 receptors in vivo.
Partial adenosine A1 receptor agonists with reduced intrinsic activity at the cardiovascular system would be promising for therapeutic application (e.g., as antilipolytic agents). In the present study a series of 8-alkylamino [methyl (M)-, ethyl (E)-, propyl (P)-, butyl (B)- and cyclopentyl (CP)-] derivatives of N6-cyclopentyladenosine (CPA) were investigated in conscious normotensive rats. Aft...
متن کاملselective inhibitory effect of adenosine a1 receptor agonists on the proliferation of human tumor cell lines
background: in this study, the effects of three structural analogues of adenosine upon proliferation of human tumor cells were investigated. previous research showed a cytotoxic effect of adenosine via a3 receptor and a1 receptor and sometimes this effect was receptor independent. the researches showed a differential cytotoxic effect of adenosine and its a3 agonists on cancerous cells, while ot...
متن کاملLate preconditioning induced by NO donors, adenosine A1 receptor agonists, and delta1-opioid receptor agonists is mediated by iNOS.
Although ischemia-induced late preconditioning (PC) is known to be mediated by inducible nitric oxide (NO) synthase (iNOS), the role of this enzyme in pharmacologically induced late PC remains unclear. We tested whether targeted disruption of the iNOS gene abrogates late PC elicited by three structurally different NO donors [diethylenetriamine/NO (DETA/NO), nitroglycerin (NTG), and S-nitroso-N-...
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ژورنال
عنوان ژورنال: Purinergic Signalling
سال: 2011
ISSN: 1573-9538,1573-9546
DOI: 10.1007/s11302-011-9274-3